Progress of the functions and active mechanisms of sepsis associated microRNAs and their diagnostic value / 中华检验医学杂志
Chinese Journal of Laboratory Medicine
;
(12): 1007-1013, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-800239
ABSTRACT
Sepsis is a syndrome encompassing a uncertain pathobiology and threatens the health of human being. The new definition of sepsis indicates that sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The exacerbation of inflammation accompanied with dysregulation of immunosuppression leads to the complicated changes of pathophysiology in sepsis. MicroRNAs (miRNAs) perform vital roles in the regulations of inflammation responses as well as organ damages associated with sepsis. The variety in the expression level of miRNA appears in the development of sepsis; monitoring and analyzing miRNA levels contributes to the diagnosis and prognosis of the disease. Controlling the expression levels of miRNAs related with sepsis is able to alleviate the organ damages and dysfunctions caused by the disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Journal of Laboratory Medicine
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS