Your browser doesn't support javascript.
loading
Novel targets for ischemia reperfusion injury therapy in the liver / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery ; (12): 948-951, 2019.
Article in Chinese | WPRIM | ID: wpr-800421
ABSTRACT
Liver ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver transplantation, and other liver surgeries. It’s important to study the targets towards liver IRI for preventing and mitigating the clinical renal injury. It has been reported that the peroxisome proliferator activated receptor gamma (PPARγ) protects the liver against IRI by targeting family with sequence similarity 3 member A (FAM3A). At the meantime, noncoding RNAs, including lncRNAs and miRNAs, have also been reported to play important roles on the process of hepatic IRI. This review briefly discussed the roles and mechanisms of PPARγ, FAM3A and noncoding RNAs in liver IRI, to find potential targets of gene therapy, aiming to prevent and mitigate the liver IRI as well as to improve postoperative liver function.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Hepatobiliary Surgery Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Hepatobiliary Surgery Year: 2019 Type: Article