Clinical value of prothrombin time and hepatic thromboplastin test in the diagnosis of hepatic fibrosis staging of chronic hepatitis B virus / 中国基层医药

ABSTRACT

Objective@#To investigate the clinical value of prothrombin time(PT) and hepatic thromboplastin test(HPT) in the diagnosis of hepatic fibrosis stage in patients with chronic hepatitis B.@*Methods@#A total of 76 patients with chronic hepatitis B in Yuncheng Central Hospital from January 2015 to January 2016 were selected.The plasma PT and HPT levels were measured in patients with different stages of liver fibrosis and healthy people.The sensitivity, specificity and accuracy were determined.The clinical value of PT and HPT indicators in liver fibrosis stages was analyzed.@*Results@#The levels of PT and HPT in patients with chronic viral hepatitis B increased significantly with the severity of hepatic fibrosis.The level of PT in stage S4 [(14.86±0.96)s] was significantly higher than that in stage S1[(13.31±0.49)s], S2[(13.43±0.52)s] and S3[(13.66±0.53)s](P<0.05). The level of HPT in stage S3[(19.33±1.14)s] was significantly higher than that in stage S1[(17.74±0.82)s] and stage S2[(18.12±0.95)s], the difference was significant (P<0.05). The level of HPT in stage S4[(20.27±1.39)s] was significantly different from that in stage S1[(17.74±0.82)s], S2[(18.12±0.95)s] and stage S3[(19.33±1.14)s](P<0.05). The sensitivity, specificity and accuracy of PT and HPT in liver fibrosis stage(>S2, S4) were higher by drawing ROC curve analysis.@*Conclusion@#The sensitivity and specificity of PT and HPT are high.They have good clinical diagnostic value in staging liver fibrosis in patients with chronic hepatitis B.