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Evaluating the impact of psoriasis on cognitive function in mouse models by using Morris water maze / 中华皮肤科杂志
Chinese Journal of Dermatology ; (12): 836-839, 2019.
Article in Chinese | WPRIM | ID: wpr-801224
ABSTRACT
Objective@#To evaluate the impact of psoriasis on spatial learning and memory abilities in mouse models by using Morris water maze.@*Methods@#Twenty healthy male C57BL/6J mice aged 10 months were randomly and equally divided into 2 groups psoriasis group topically treated with imiquimod 5% cream on the back once a day for a week, and control group topically treated with vaseline once a day for a week. After successful establishment of mouse models, the Morris water maze (MWM) test was used to assess the learning and memory abilities in the mice in the 2 groups.@*Results@#In the place navigation experiment, the escape latency was significantly longer in the psoriasis group (38.24 ± 13.59 s) than in the control group (14.28 ± 3.80 s, t = 5.37, P < 0.01) . In the spatial probe test, the number of times passing through the platform (1.70 ± 0.95 vs. 5.00 ± 1.76, t = 5.21, P < 0.01) , the duration of stay in the target quadrant (t = 2.80, P < 0.05) and the swimming distance (t = 5.74, P < 0.01) were all significantly lower in the psoriasis group than in the control group. The psoriasis group showed significantly decreased swimming distance in the second quadrant (t = 2.49, P < 0.05) , but significantly longer duration of stay in the fourth quadrant compared with the control group (t = 2.46, P < 0.05) . There were no significant differences in swimming distance or duration of stay in other quadrants between the psoriasis group and control group (all P > 0.05) .@*Conclusion@#The spatial learning and memory abilities were impaired in the mouse model of psoriasis.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Dermatology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Dermatology Year: 2019 Type: Article