Clinical value of 99Tcm-MIBI SPECT/CT in the diagnosis of hyperparathyroidism / 中国医师杂志

ABSTRACT

Objective@#To evaluate the clinical value of 99Tcm- sestamibi (MIBI) single photon emission computed tomography/computerized tomography (99Tcm-MIBI SPECT/CT) imaging in hyperparathyroidism (HPT), and to investigate the diagnostic significance of different phase tomographic imaging and compare with 99Tcm-MIBI dual phase plane imaging.@*Methods@#All 54 patients underwent 99Tcm-MIBI dual-phase planar imaging, 99Tcm-MIBI SPECT/CT early tomographic fusion imaging, delayed tomographic fusion imaging. According to the clinical diagnostic criteria, the sensitivity of three imaging methods in the diagnosis of hyperparathyroidism and the lesions was analyzed.@*Results@#⑴ The diagnostic sensitivity of the 99Tcm-MIBI dual-phase planar imaging was 75.9%(41/54). The diagnostic sensitivity of the 99Tcm-MIBI SPECT/CT early tomographic fusion imaging was 88.9%(48/54). The diagnostic sensitivity of 99Tcm-MIBI SPECT/CT delayed tomographic fusion imaging was 77.8%(42/54). ⑵ There were 74 lesions diagnosed by 99Tcm-MIBI dual phase planar imaging, 95 lesions diagnosed by 99Tcm-MIBI SPECT/CT early stage fusion imaging, and 78 lesions diagnosed by 99Tcm-MIBI SPECT/CT delayed fusion imaging. The detection rate of positive lesions in early stage tomography was the highest. ⑶ There were 4 cases of ectopic parathyroid lesions diagnosed by early CT fusion imaging, 3 cases by dual phase planar imaging and delayed CT fusion imaging.@*Conclusions@#99Tcm-MIBI SPECT/CT is an effective method to locate the focus of HPT, especially early tomographic fusion imaging combined with serum parathyroid hormone (PTH) value can improve the diagnostic efficiency.