To explore the treatment mechanism of Wenpi decoction on ulcer colitis based on integrative pharmacology of traditional Chinese medicine platform / 国际中医中药杂志

ABSTRACT

Objective@#The active components and potential targets were predicted and confirmed to explore the possible mechanism of Wenpi decoction on ulcer colitis.@*Methods@#The traditional Chinese medicine integrated pharmacology platform (TCMIP) was used to construct the decoction-target-disease target network, and the key nodes were analyzed and screened. The function and pathway enrichment analysis were conducted to explore the biological processes, which Wenpi decoction may be involved in the treatment of ulcerative colitis.@*Results@#The study showed that there were 455 active ingredients and 3044 targets in Wenpi decoction. The 434 targets and multiple biological processes and metabolic pathways were involved, such as chemokine signaling pathways, estrogen signaling pathway, thyroid hormone signaling pathway, MAPK signaling pathway, and PI3K/Akt signaling pathway. These targets and pathways were consistent with the pathogenesis of ulcerative colitis reported in the literature. In addition, Wenpi decoction was potential to be applied in the treatment of tumor, endocrine and metabolic diseases.@*Conclusions@#This study provided a scientific basis for further studies on the mechanism of Wenpi decoction in the treatment for ulcer colitis.