IL-17 gene rs763780 polymorphism and susceptibility of gastric cancer：a Metaanalysis / 中国肿瘤生物治疗杂志

ABSTRACT

@# Objective: To assess the association between interleukin-17 (IL-17) gene rs763780 polymorphism and susceptibility of gastric cancer using Meta-analysis. Methods: A comprehensive search was performed on PubMed, EMBASE, the Cochrane Library, Web of Science, Wanfang Database, Chinese Biomedical Literature Database, Chinese Science and Technology Academic Journal and Chinese Journal Full-text Database from their inception to December 2017 to identify relevant case-control studies on association between interleukin-17 (IL-17) gene rs763780 polymorphism and susceptibility of gastric cancer. Meta-analysis was performed using STATA 12.0 software. Results: A total of 10 case-control studies were included in this Meta-analysis, involving 3 892 gastric cancer cases and 4 627 controls. The results showed that there was association between IL-17 rs763780 polymorphism and gastric cancer risk in allele genetic model (C vs T OR=1.90, 95% CI=1.73-2.08), additive model (CC vs TT OR=1.76, 95% CI=1.45-2.14), codominant model (CC vs CT OR =1.26, 95% CI=1.13-1.42), dominant model (CC vs CT+TT OR=1.93, 95% CI=1.65-2.26) and recessive model (TT vs CT+CC OR=1.67, 95% CI=1.38-2.03). Conclusion: IL-17 rs763780 polymorphism increases the risk of gastric cancer.