Prevention and Treatment Effect of Traditional Chinese Medicine for Stroke Based on Regulating Gut Microbiome / 中国实验方剂学杂志

ABSTRACT

The gut microbiome is a unique ecosystem, known as the "forgotten organ" of the human body, and the "second genome" of human. Gut microbiome imbalance is associated with many central nervous system diseases such as Parkinson's disease, Alzheimer's disease, schizophrenia and disseminated sclerosis. Stroke is characterized by high morbidity, recurrence, mortality, and disability. Gut microbiome plays a key role in the occurrence and development of stroke, which can further affect the onset of stroke by affecting the body's absorption, metabolism, blood pressure, blood sugar, blood lipids and atherosclerotic plaque. In Chinese medicine, it is believed that the spleen and stomach qi and blood flow loss, the Yin and yang imbalance, the body's physiological dysfunction, metaplasia "wind, fire, phlegm, deficiency, silt" and other pathological products, can cause the occurrence of stroke. The spleen and stomach are mainly involved for decomposing food, transporting and transforming nutrients from foodstuff, and the gut microbiome affect the digestion and absorption of the diet. The function of gut microbiome in modern research is related to the dysfunction of the spleen and stomach in Chinese medicine. Therefore, adjusting the homeostasis of the gut microbiome can be used as a potential intervention target to prevent and treat ischemic stroke. Traditional Chinese medicine(TCM) intervention has already achieved good results in stroke, and whether it is related to the regulation effect of gut microbiome is worthy of further research in the future. At the same time, the research progress of active ingredients in TCM (berberine, baicalin, resveratrol, et al), single TCM prescriptions (Salviae Miltiorrhizae Radix Et Rhizoma, Rhodiolae Crenulatae Radix Et Rhizoma, et al) and compound TCM prescriptions (Buyang Huanwu Tang, Naoxintong capsule, Buzhong Yiqi Tang) in prevention and treatment of cerebral ischemia were reviewed in this study, providing new ways and ideas for the prevention of ischemic stroke and development of new therapies.