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Clinical Efficiency of Modified Yuyetang to Type 2 Diabetes Mellitus Combined with Coronary Heart Disease / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 78-83, 2019.
Article in Chinese | WPRIM | ID: wpr-801835
ABSTRACT

Objective:

To discuss the clinical effect of modified Yuyetang to type 2 diabetes mellitus (T2DM) combined with coronary heart disease (deficiency of Qi and Yin or phlegm syndrome and stasis syndrome) and the mechanisms of anti-inflammation and anti-oxidation.

Method:

One hundred and eighteen patients were randomly divided into control group (58 cases) and observation group (60 cases) by random number table. Patients in control group was orally given insulin or special blood glucose for hypoglycemic agents, aspirin enteric-coated tablets, 100 mg/time, 1 time/day. Patients with dyslipidemia got atorvastatin, 10 mg/time, 1 time/day. And patients with hypertension got captopril tablets, 12.5-25.0 mg/time, 1 time/day. In addition to the therapy of control group, patients in observation group were also given modified Yuyetang, 1 dose/day. A course of treatment was 3 months. Before and after treatment, levels of glycated hemoglobin (HbA1c), fasting blood glucose (FPG), 2-hours postprandial glucose (2 hPG), blood lipids triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HLD-C), low-density lipoprotein (LDL-C), apolipoprotein A (ApoA), apolipoprotein B (ApoB), procalcitonin (PCT), homocysteine (Hcy), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and hypersensitive C-reactive protein (hs-CRP), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and 8-Isoprostaglandin F2a (8-ios-PGF2a) were detected, Gensini and traditional Chinese medicine (TCM) syndrome were scored, and electrocardiogram was detected.

Result:

After treatment, levels of FPG, HbA1c, LDL-C, ApoB, scores of Gensini and TCM syndrome, PCT, Hcy, IL-6, TNF-α and hs-CRP in observation group were all lower than those in control group (PPPPPP

Conclusion:

In addition to hypoglycemic, lipid-lowering and antiplatelet therapies, Modified Yuye decoction can regulate glucose and lipid metabolism of patients with T2DM and coronary heart disease, relieve degree of coronary artery stenosis, with anti-inflammatory and anti-oxidative stress effect.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2019 Type: Article