Clinical Efficacy of Xiaoxuan Zhiyun Tablet in Treating Cervical Vertigo with Syndrome of Phlegm and Blood Stasis Resistance / 中国实验方剂学杂志

ABSTRACT

Objective:To observe the efficacy of Xiaoxuan Zhiyun tablet in treating cervical vertigo with syndrome of phlegm and blood stasis resistance and its effect on oxidative stress and serum levels of endothelin-1(ET-1), 5-hydroxytryptamine (5-HT), and nitric oxide (NO). Method:One hundred eighteen cervical vertigo cases were selected and randomly divided into control group (59 cases) and treatment group (59 cases) by random number table. Control group was given bone setting combined with acupuncture. In addition to the therapy of control group, treatment group was given Xiaoxuan Zhiyun tablet (1 dose/day, tid). Both groups were treated for 3 weeks. Scores of cervical vertigo symptom and function assessment scale (ESCV) and vertigo disorder scale (DHI), blood velocity of vertebrobasilar artery, life quality and efficacy were compared between both groups. Serum levels of superoxide dismutase (SOD), malondialdehyde (MDA), ET-1, 5-HT and NO were detected in both groups. Result:After treatment, ESCV score of treatment group was obviously higher, while DHI score was lower than control group (PPPPPConclusion:In addition to the routine therapy, the efficacy of Xiaoxuan Zhiyun tablet in treating cervical vertigo is significant, which may be related with regulation of oxidative stress and serum levels of ET-1, 5-HT and NO.