Research Progress on Pharmacological Effect and Clinical Application of Traditional Chinese Medicinal Pair in Treatment of Diabetic Nephropathy / 中国实验方剂学杂志

ABSTRACT

Medicinal pair is the cornerstone in compatibility of traditional Chinese medicine prescriptions in clinical application.At present,there are many related studies on Chinese medicine for diabetic nephropathy,but they mainly focus on efficacy observation and prescription summary,lacking in-depth study and summary of the mechanism of action of traditional Chinese medicine (TCM).As compared with prescriptions,Chinese medicinal pair has fewer chemical components,a single form,simple mechanism of action,and fewer interference factors.In recent years,TCM has accumulated rich clinical practice experience in the treatment of diabetic nephropathy.Many researchers pay great attention to the application of medicinal pairs in the compatibility of prescriptions and their action rules.Through the compatibility of medicinal pairs,the optimized combinations can be achieved from various aspects to further improve the therapeutic effect of TCM compound.In order to clarify the ways and targets of Chinese medicinal pairs in treatment of diabetic nephropathy,relevant articles at home and abroad were systemically reviewed in this paper.For the clinical observation and animal experiments of the past 10 years,four types of medicines with "invigorating the spleen and the kidney" ,"clearing damp and promoting diuresis" "activating blood and removing stasis" and "securing and astringing" with curative effect for diabetic nephropathy,were mentioned in this article.The composition rules and the progress of experimental researches of these medicinal pairs were analyzed,while the compatibility principles,chemical compositions,and pharmacokinetic changesof the medicinal pairs were summarized to provide some references for their further application,researches and development.