Effect of Yiqi Huoxue Tongmai Method in Treating Atherosclerotic Lesions of Lower Extremity of Diabetes / 中国实验方剂学杂志

ABSTRACT

Objective:To observe the effect of Yiqi Huoxue Tongmai method in treating lower extremity atherosclerotic disease (LEAD) and on hemodynamic index and vascular endothelial function. Method:One hundred and five patients were randomly divided into control group (52 cases) and observation group (53 cases) by random number table. Patients in control group were treated for controlling blood sugar, blood fat, blood pressure and given aspirin enteric-coated tablets, 100 mg/day, cilostazol tablets, 100 mg/day, 2 times/day. In addition to the therapy of control group, patients in observation group were given modified Danggui Sini Tang and Buyang Huanwu Tang for oral and washout, 1 dose/day. The treatment course lasted for 12 weeks. Before and after treatment, ankle brachial index (ABI) was detected. And intimal thickness of shallow femoral shallower, arteriae tibialis posterior and arteriae dorsalis pedis, hardening degree, patch size and degree of stenosis were detected by color Doppler ultrasound diagnostic apparatus. Qi deficiency and blood stasis syndrome were scored. And levels of the whole blood viscosity, plasma viscosity, erythrocyte sedimentation rate (ESR), D-dimer (D-D), fibrinogen (FIB), erythrocyte electrophoresis, fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), serum 25-hydroxyvitamin D3 ([25(OH)D3]), endothelin (ET), nitric oxide (NO) and homocysteine (Hcy) were detected. Result:By the rank sum test, the clinical effect in observation group was better than that in control group (Z=2.371, PPPPPP3] and NO were higher than those in control group (PConclusion:Modified Danggui Sini Tang and Buyang Huanwu Tang can ameliorate hemodynamics and vascular endothelial function, improve ABI, relieve arteriosclerosis and narrow degrees, and alleviate clinical symptoms.