Anti-hepatic Fibrosis Mechanism of Cordyceps Polysaccharide / 中国实验方剂学杂志

ABSTRACT

Hepatic fibrosis is a repair process of the liver in response to various chronic injuries. The unbalanced proliferation and decomposition of fibrous tissue in the liver causes the excessive deposition of fibrous connective tissue in the liver. Hepatic fibrosis is a common intermediate link in a variety of chronic liver diseases. In this pathological process, the interaction between cells and cytokines leads to the disorder of liver extracellular matrix metabolism, which results in excessive deposition of fibrous tissue in the liver, and eventually causes liver fibrosis. After continuous deterioration, it would gradually develop into liver cirrhosis and even liver cancer. Because liver fibrosis and liver cirrhosis can be reversed in the early stage, it is very important to control the reversible process of liver fibrosis for the prevention and treatment of liver cirrhosis and liver cancer. Cordyceps, as one of valuable medicinal fungi in China, has been given widespread attention from scientific workers, with broad pharmacological actions. Cordyceps polysaccharide is the highest content of bioactive substances in Cordyceps. Recent studies have found that it has an anti-hepatic fibrosis effect. With the application of molecular biology technology, researches on the anti-liver fibrosis mechanism of traditional Chinese medicine at home and abroad have been gradually deepened into the cellular and molecular levels. This paper will investigate the preventive effect of Cordyceps polysaccharide in terms of cell basis, cytokines, collagenase and lipid peroxidation level that are related to liver fibrosis, so as to clarify the specific action mechanism on anti-hepatic fibrosis, and provide a reference for the development of anti-hepatic fibrosis drugs.