Clinical Effect of Modified Tongqiao Huoxuetang Combined with ‘Huiyang Jiuzhen’ in Treating Post-stroke Cognitive Impairment / 中国实验方剂学杂志

ABSTRACT

Objective: To discuss the clinical efficacy of modified Tongqiao Huoxuetang combined with ‘Huiyang Jiuzhen’ in treating post-stroke cognitive impairment (PSCI) and its mechanisms in resisting inflammation and oxidant stress and ameliorating hemorheology. Method: One hundred and twenty-two patients were randomly divided into control group (61 cases) and observation group (61 cases) by random number table. Both groups got Donepezil tablets, 10 mg/time, 1 time/day, and Nicergoline tablets, 20 mg/time, 3 times/days. Patients in control group got ‘Huiyang Jiuzhen’, 1 time/day, 6 times/week. In addition to the therapy in control group, patients in observation group got modified Tongqiao Huoxuetang, 1 dose/day. And a course of treatment was 8 weeks. Before treatment and at the 4th week and 8th week after treatment, scores of mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) were discussed. And activity of daily living scale (ADL), syndrome of blood stasis and cerebral collaterals were graded. And levels of Interleukin-6 (IL-6) before and after treatment, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), oxidized low density lipoprotein (Ox-LDL), superoxide dismutase (SOD), malondialdehyde (MDA), hemorheology were detected. Result: According to the rank sum test, the clinical efficacy in observation group was better than that in control group (Z=1.976, Pth week and 8th week after treatment, score of MMSE and MoCA were higher than that in control group (PPPα, CRP, DA and Ox-LDL were lower than those in control group (PPPConclusion: In addition to the routine therapy of western medicine, modified Tongqiao Huoxuetang combined with ‘Huiyangjiuzhen’ can improve patients cognitive function and daily life ability, have effects in resisting inflammation and oxidation and ameliorating hemorheology, and can promote the recovery of cognitive function.