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Effects of Shenyankangfu tablets combined with losartan on cellular immune function, inflammatory factors and renal function in patients with chronic glomerulonephritis / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1986-1989, 2019.
Article in Chinese | WPRIM | ID: wpr-802822
ABSTRACT
Objective@#To investigate the effects of Shenyankangfu tablets combined with losartan on cellular immune function, inflammatory factors and renal function in patients with chronic glomerulonephritis.@*Methods@#From March 2017 to March 2018, 94 patients with chronic glomerulonephritis admitted to Hangzhou Dajiangdong Hospital were randomly divided into observation group (47 cases) and control group (47 cases). The control group was treated with losartan, and the observation group was treated with Shenyankangfu tablets on the basis of the control group.The two groups were treated for 12 weeks.The changes of cellular immune function, inflammatory factors and renal function were compared between the two groups before and after treatment.@*Results@#After treatment, the levels of CD4+(71.98±3.28)%, CD4+(40.01±3.86)% and CD4+/CD8+ (1.54±0.23) in the observation group were higher than those in the control group [(64.32±4.01)%, (34.87±1.96)% and (1.23±0.16)] (t=10.137, 8.140, 7.585, all P<0.05). After treatment, the level of IL-2 in the observation group [(3.18±0.59)μg/L] was higher than that in the control group [(2.37±0.71)μg/L], while the levels of IL-6[(227.42±12.41)ng/L] and TNF-α [(2.45±0.29)ng/L] in the observation group were lower than those in the control group [(289.64±19.36)ng/L and (3.38±0.65) ng/L] (t=6.015, 18.549, 8.958, all P<0.05). After treatment, the levels of Scr [(123.49±8.97)μmol/L], Upro[(0.76±0.18)g/24h] and BUN[(6.71±0.5)mmol/L] in the observation group were lower than those in the control group [(159.51±7.41)μmol/L, (1.28±0.23)g/24h, (7.91±0.47)mmol/L](t=21.224, 12.206, 11.136, all P<0.05). The total effective rate of the observation group (93.62%) was higher than that of the control group (72.34%) (P<0.05).@*Conclusion@#Shenyankangfu tablets combined with losartan can improve the cellular immune function and renal function in patients with chronic glomerulonephritis, and can reduce inflammatory reaction.The curative effect is remarkable, which is worthy of clinical reference.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2019 Type: Article