Clinical value of cystatin C in predicting severe pneumonia / 中国基层医药

ABSTRACT

Objective@#To analyze the expression and clinical significance of cystatin C in patients with severe pneumonia.@*Methods@#The retrospective study method was used to collect 213 CAP patients who were hospitalized in Department of Respiration, Shengjing Hospital Affiliated to China Medical University from January 2016 to June 2018, in accordance with the inclusion and exclusion criteria, 95 cases in severe pneumonia group, and 118 cases of non severe pneumonia group.The clinical data of blood creatinine, blood urea nitrogen, cystatin C, C reactive protein(CRP) concentration and CURB-65(confusion, urea, respiratory rate, blood pressure, age>65 years) score were analyzed in the two groups, and the clinical risk factors of severe pneumonia and non severe pneumonia were compared.@*Results@#In the severe pneumonia group, the values of cystatin C, blood urea nitrogen and CRP were (1.32±0.47)mg/L, (7.73±5.79)mmol/L and (127.25±81.49)mg/L, respectively, which in the non severe pneumonia group were (1.06±0.33)mg/L, (5.06±2.41)mmol/L and (45.50±44.28)mg/L, respectively, the differences between the two groups were statistically significant (t=4.469, 4.218, 8.789, all P<0.05). The CURB-65 scores between the two groups had statistically significant difference(Z=-6.892, P<0.05). Logistic regression analysis showed that cystatin C and CRP were independent risk factors for severe pneumonia.@*Conclusion@#The cystatin C level in patients with severe pneumonia is higher than that of patients with non severe pneumonia patients, suggesting that cystatin C has clinical value in predicting severe pneumonia and should be paid enough attention.