Correlation analysis of antibody titer and immune balance after infection of mycoplasma pneumoniae in children with bronchial asthma / 中国基层医药

ABSTRACT

Objective@#To study the correlation of antibody titer and immune balance after infection of mycoplasma pneumoniae in children with bronchial asthma.@*Methods@#From October 2010 to August 2015, 108 children with bronchial asthma infected with mycoplasma pneumoniae were selected.There were 71 patients in the observation group, children with mycoplasma pneumoniae antibody titers >1∶160, and 37 cases were selected as control group, mycoplasma pneumonia antibody titer≤1∶160.The titer of mycoplasma antibody, serum interferon gamma(IFN-γ), interleukin-4(IL-4) and interleukin-17(IL-17) were measured.@*Results@#The serum IFN-γ, IL-4 and IL-17 levels in the control group were (41.04±3.13)μg/L, (17.04±3.16)μg/L and (30.81±4.23)μg/L, respectively, which in the observation group were (33.26±3.17)μg/L, (24.15±5.09)μg/L and (41.29±5.09)μg/L, respectively.The serum IL-4 and IL-17 levels of the observation group were significantly higher than those of the control group(t=5.126, 3.429, all P<0.05). After infection of mycoplasma pneumoniae, the serum IFN-γ in the observation group decreased significantly(t=4.168, P<0.05).@*Conclusion@#The titer of antibody after mycoplasma pneumoniae infection in children with bronchial asthma is closely related to the immune balance.The higher the antibody titer, the more serious the immune imbalance.