Numerical analysis on flow field in a vascular bioreactor / 医用生物力学

ABSTRACT

Objective To study the flow field of a new vascular bioreactor with small diameter at different operating conditions. Method To investigate the flow field of a new vascular bioreactor with small diameter under three operating conditions by numerical simulation outer box rotating, inner box rotating and both inner box and outer box rotating. A comparison of parameters such as flow velocity and shear stress was made. Results The culture medium in the bioreactor rotated with the inner box and outer box, and the velocity was uniformly distributed; the bioreactor could therefore provide a low shear stress environment that is nondestructive for the cells in the medium; the shear stress in bioreactor had a quadratic function relation with the rotation rate. Conclusions This bioreactor could provide a good culture environment for vascular tissue regeneration, and this study provided theoretical basis for the experimental research of bioreactors.