Analysis of Cerebral Hemorrhage Based on Microcirculation / 医用生物力学

ABSTRACT

Objective To study the effect and mechanism of capillary microcirculation disturbance on intracerebral hemorrhage. Methods The loading effect of capillaries was replaced by the introduction of porous media. A microcirculation model from the capillaries to the veins was established. The appropriate mechanical boundary conditions were set up for the model by referring to various physiological conditions of human body, and the changes in blood pressure and stress of vascular wall under various conditions were simulated. Results Under normal circumstances, the whole blood pressure of the LSA was relatively low, and the pressure difference between the beginning and the end of the LSA was more obvious, and the stress of all parts of the vascular wall was at the same level. In the case of microcirculation disorder, the whole blood pressure of the LSA increased and the pressure difference between the beginning and the end of the LSA significantly decreased. The stress for each part of the vessel increased and the stress at the end of the LSA increased most significantly. Conclusions The influence of microcirculation disturbance on hemodynamics of the LSA was particularly significant. It was an important factor leading to hemorrhage of the LSA rupture. The research findings are of important theoretical and practical significance for understanding the mechanism of cerebral vascular rupture and preventing the occurrence of cerebral hemorrhage in the case of microcirculation disturbance.