Research progress on invasion-related virulence factors in Porphyromonas gingivalis / 中华口腔医学杂志

ABSTRACT

Porphyromonas gingivalis (Pg) is a kind of gram-negative obligate anaerobes. It can invade and internalize within host cells. The invasion ability of Pg is very important for the occurrence and development of diseases and has been a hot topic for a long time. Remaining pathogenic characteristics in cell is one of its pathogenesis. In the process of invading host, the specific bacterial adhesin combine with the ligand of host cells, which activate various signal transduction pathways and trigger bacterial internalization. Virulence factors in Pg, such as fimbriae, gingival protease, hemagglutinins and outer membrane vesicles play significant roles in the process. This review summarized the research progress of the virulence factors which relate to Pg′s invasion, which provided a serious of new ideas on exploring Pg′s pathogenesis and the prevention and treatment of related diseases.