Bronchial hyperrseponsiveness to methacholine in allergic rhinitics sensitized to house dust mites / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 308-315, 1998.
Article
in Korean
| WPRIM
| ID: wpr-80491
ABSTRACT
BACKGROUND:
Allergic rhinitis is often associated with bronchial asthma, and intranasal treatment with topical corticosteroids reduces bronchial responsiveness.OBJECTIVE:
In this study, it was evaluated that the bronchial responsiveness to methacholine increased in non-asthmatic adults with house dust mites (HDM)-sensitive allergic rhinitis compared to those without, chronic nasal symptoms. SUBJECTS ANDMETHODS:
A questionnaire, skin prick t,est to common inhalant allergens, and methacholine bronchial provocation test (MBPT) were performed in a total of 216 subjects, who were composed of 40 non-asthmatic subjects with HDM-sensitive allergic rhinitis (HAR), 63 HDM-sensitive subjects without nasal symptoms (HS), and 113 non-atopic subjects without nasal symptoms (NHS). The bronchial responsiveness was evaluated by positive rate of MBPT (PC,-methacholine200mg/ml), provocative concentration of methacholine at which FEV, decline to 15% compared to baseline value (PC,-methacholine), and slope of dose-response curve (%fall of FEV, / log[last concentrat,ion of methacholine, mg/ml]).RESULTS:
Positive rate of MBPT was significantly increased in HAR than in HS and NHS, and there was no difference between HS and NHS (77.9% vs. 50.7% vs. 38.0%). Log PC[5- methacholine was lower in HAR than in HS and NHS, and lower in HS than in NHS (mean+ SE, 1.568+0.126 vs. 2.05+0.085 vs. 2.277+0.047). Slope of dose-response curve was higher in HAR than in HS and NHS, and there was no difference bet,ween HS and NHS (mean+SE, 22.7 + 11.3 vs. 7.3+ 1.2 vs. 4.9+ 0.5%/mg/ml);CONCLUSION:
In non-asthmatic adults with HDM-sensitive allergic rhinitis, the bronchial responsiveness to methacholine increased compared to those without chronic rhinitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Skin
/
Bronchial Provocation Tests
/
Allergens
/
Rhinitis
/
Surveys and Questionnaires
/
Methacholine Chloride
/
Adrenal Cortex Hormones
/
Pyroglyphidae
/
Dust
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Journal of Asthma, Allergy and Clinical Immunology
Year:
1998
Type:
Article
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