Clinical prognostic factors of adult supratentorial glioblastoma / 中华外科杂志

ABSTRACT

Objective@#To analyze the treatment effect of patients with glioblastoma (GBM) and explore prognostic factors.@*Methods@#The clinical data of 635 patients diagnosed as GBM at Neurosurgical Oncology Department Ⅳ of Beijing Tiantan Hospital, Capital Medical University from January 2007 to March 2018 were retrospectively reviewed. There were 386 males and 249 females with an age of (48.7±11.8) years (range 18-75 years). Patients were divided into three groups according to the time of admission 2007-2010 group(n=174), 2011-2014 group (n=237) and 2015-2018 group (n=224). Kaplan-Meier plot was used to analyze the effects of different treatment periods, treatment schemes and clinical factors on the survival of patients with GBM. Cox proportion hazard regression analysis was used to identify independent prognostic factors.@*Results@#The median progression-free survival (PFS) and overall survival (OS) of patients in 2007-2010 group, 2011-2014 group, 2015-2018 group was 9.0 months (95% CI 7.5-10.5), 10.0 months (95% CI 8.8-11.2), 12.0 months (95% CI 10.7-13.3) and 17.0 months (95% CI 13.2-20.8), 20.0 months (95% CI 16.9-23.1), 23.0 months(95% CI 17.5-28.5), respectively. The PFS and OS of patients improved significantly over the years (χ2=9.693, P=0.008 and χ2=8.616, P=0.013). Multivariate survival analysis showed that age, extent of resection, radiotherapy and tumor distant dissemination were independent prognostic factors (all P<0.05).@*Conclusions@#With the continuous development of clinical treatment regimen, the therapeutic effect of Chinese GBM patients has improved remarkably. Age, extent of resection, radiotherapy and tumor distant dissemination are independent prognostic factors associated with survival time.