Efficacy of soluble hyaluronic acid microneedle on removing suborbital wrinkles / 中华医学美学美容杂志

ABSTRACT

Objective@#To investigate the clinical efficacy and safety of soluble hyaluronic acid microneedle eye patch on infraorbital wrinkles.@*Methods@#Seventy-five female subjects in Beijing and Shanghai were recruited and treated with soluble hyaluronic acid microneedle patch two days a week at the left lower eyelid (experimental side) and at least 30 minutes each time for 12 weeks. Investigator visual assessment, instrumentation measurement for skin moisture, elasticity, wrinkle area and depth were performed at week 0 (pre-treatment) and week 4 and week 12 and compared to the right (control side). The safety was assessed by documenting adverse reactions occurring during the study. Subject satisfaction was assessed at week 12.@*Results@#After 12 weeks of treatment, the visual assessment of skin wrinkles on experimental side (n=41, 54.67%) was significantly improved as comparied with that on control side (n=14, 18.67%). The skin hydration of treatment side skin increased with treatment time (t=-0.488 at week4, t=-3.054 at week 12, P<0.05). After 12 weeks of treatment, skin elasticity of the experimental side improved significantly. The improvement rate of the experimental side was more than that of the control side (t=2.724, P<0.05). The wrinkle area was significantly decreased in 4 and 12 weeks compared with pre-treatment (t=4.442 at week 4 and t=3.802 at week 12, P<0.001). The depth of wrinkles of the experimental side shallowed with the treatment (t=-2.435 at week 4 and t=-3.433 at week 12, P<0.05). Only 8% (n=6) of the subjects had temporary slight pruritus or acupuncture sensation on the treatment side, and no other adverse reactions occurred. The overall subject satisfaction rate was 88%(n=66).@*Conclusions@#Soluble hyaluronic acid microneedle eye patch is effective in improving wrinkles, skin elasticity and hydrating, and has no obvious adverse reaction.