Increasing and Worsening Late Effects in Childhood Cancer Survivors during Follow-up
Journal of Korean Medical Science
;
: 755-762, 2013.
Article
in English
| WPRIM
| ID: wpr-80571
ABSTRACT
Recent advances in childhood cancer treatment have increased survival rates to 80%. Two out of three survivors experience late effects (LEs). From a group of 241 survivors previously described, 193 were followed at the long-term follow-up clinic (LTFC) of Severance Hospital in Korea; the presence of LEs was confirmed by oncologists. We reported the change in LEs during 3 yr of follow-up. The median follow-up from diagnosis was 10.4 yr (5.1-26.2 yr). Among 193 survivors, the percentage of patients with at least one LE increased from 63.2% at the initial visit to 75.1% at the most recent visit (P = 0.011). The proportion of patients having multiple LEs and grade 2 or higher LEs increased from the initial visit (P = 0.001 respectively). Forty-eight non-responders to the LTFC were older and had less frequent and severe LEs than responders at initial visit (all P < 0.05). In multivariate analysis, younger age at diagnosis, older age at initial visit, a diagnosis of a brain tumor or lymphoma, and use of radiotherapy were significant risk factors for LEs (all P < 0.05). Adverse changes in LEs were seen among the survivors, regardless of most clinical risk factors. They need to receive comprehensive, long-term follow up.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Severity of Illness Index
/
Brain Neoplasms
/
Hematopoietic Stem Cells
/
Multivariate Analysis
/
Survival Rate
/
Risk Factors
/
Follow-Up Studies
/
Age Factors
/
Hematopoietic Stem Cell Transplantation
/
Disease Progression
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2013
Type:
Article
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