Transforming growth factor-β signaling pathway and targeted therapy in ovarian cancer / 国际肿瘤学杂志

ABSTRACT

The transforming growth factor-β (TGF-β) is a polypeptide cytokine, belonging to the TGF-β superfamily. TGF-β signaling pathway can regulate cell biological activity and play a bidirectional regulatory role in the development and progression of cancer. TGF-β signaling pathway can cause the occurrence and development of ovarian cancer through various processes including inducing cell excessive proliferation, influencing tumor microenvironment and regulating immune evasion. Targeted therapy with TGF-β as a biomar-ker for ovarian cancer provides a new way to improve the prognosis of patients.