Research progress of synthetic methods of [18F]F-DOPA / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 357-363, 2019.
Article
in Zh
| WPRIM
| ID: wpr-805862
Responsible library:
WPRO
ABSTRACT
@#[18F]6-fluoro-3, 4-dihydroxy-L-phenylalanine([18F]F-DOPA)has been used as a radiotracer for Parkinson′s disease over 30 years. The previously reported electrophilic synthesis method has low radiochemical yield(RCY), low specific activity(SA)and other defects. Recent reported nucleophilic synthesis of [18F]F-DOPA could overcome the disadvantages. In this paper, the nucleophilic synthetic methods for [18F]F-DOPA are reviewed.
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WPRIM
Language:
Zh
Journal:
Journal of China Pharmaceutical University
Year:
2019
Type:
Article