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Eosinophils Modulate CD4+ T Cell Responses via High Mobility Group Box-1 in the Pathogenesis of Asthma
Allergy, Asthma & Immunology Research ; : 190-194, 2015.
Article in English | WPRIM | ID: wpr-80637
ABSTRACT
Eosinophils have been reported to modulate T cell responses. Previously, we reported that high-mobility group box 1 protein (HMGB1) played a key role in the pathogenesis of asthma. This study was conducted to test our hypothesis that eosinophils could modulate T cell responses via HMGB1 in the pathogenesis of asthma characterized by eosinophilic airway inflammation. We performed in vitro experiments using eosinophils, dendritic cells (DCs), and CD4+ T cells obtained from a murine model of asthma. The supernatant of the eosinophil culture was found to significantly increase the levels of interleukin (IL)-4 and IL-5 in the supernatant of CD4+ T cells co-cultured with DCs. HMGB1 levels increased in the supernatant of the eosinophil culture stimulated with IL-5. Anti-HMGB1 antibodies significantly attenuated increases of IL-4 and IL-5 levels in the supernatant of CD4+ T cells co-cultured with DCs that were induced by the supernatant of the eosinophil culture. In addition, anti-HMGB1 antibodies significantly attenuated the expressions of activation markers (CD44 and CD69) on CD4+ T cells. Our data suggest that eosinophils modulate CD4+ T cell responses via HMGB1 in the pathogenesis of asthma.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / Dendritic Cells / T-Lymphocytes / Interleukins / Interleukin-4 / Interleukin-5 / HMGB1 Protein / Eosinophils / Inflammation / Antibodies Type of study: Etiology study / Prognostic study Language: English Journal: Allergy, Asthma & Immunology Research Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / Dendritic Cells / T-Lymphocytes / Interleukins / Interleukin-4 / Interleukin-5 / HMGB1 Protein / Eosinophils / Inflammation / Antibodies Type of study: Etiology study / Prognostic study Language: English Journal: Allergy, Asthma & Immunology Research Year: 2015 Type: Article