T-lymphocyte subsets in peripheral blood of children with hand, foot and mouth disease: a Meta analysis / 中华实验和临床病毒学杂志

ABSTRACT

Objective@#To evaluate the changes of T-lymphocyte subsets in peripheral blood of children with hand, foot and mouth disease(HFMD).@*Methods@#CNKI, Wanfang, VIP, CBM, PubMed, and Springerlink were searched for articles published from January 2014 to October 2017 with "HFMD, lymphocyte subsets, T-lymphocyte subsets" . Two reviewers selected the studies and extracted the data independently. We performed data analysis using RevMan 5.3 and Stata 14.0 software.@*Results@#Twenty-three studies were included in this meta-analysis. Mild vs. severe The mean difference (MD) and 95% CI of CD3+ CD4+ T cells, CD3+ CD8 + T cells, CD3+ T cells and CD4/CD8 were 7.27 (5.91, 8.63), 3.40 (0.68, 6.12), 11.56 (8.59, 14.53), 0.24 (0.14, 0.34), higher than the severe group. Mild vs. control The MD and 95% CI of CD3+ CD4+ T cells, CD3+ CD8+ T cells, CD3+ T cells and CD4/CD8 were -5.62 (-7.16, -4.07), -1.79 (-2.79, -0.79) -6.85 (-9.63, -4.07), -0.27 (-0.48, -0.05) respectively, lower than those in healthy controls. Severe vs. Ccontrol The MD and 95% CI of CD3+ CD4+ T cells, CD3+ CD8+ T cells, CD3+ T cells and CD4/CD8 were -12.03 (-14.99, -9.07), -5.45 (-7.47, -3.43) -18.52 (-24.92, -12.12), -0.46 (-0.71, -0.20) respectively, lower than those in healthy controls.@*Conclusions@#T-lymphocyte subsets in children with HFMD were related to their condition of disease and declined as the disease worsened.