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Additive Effect of Oral Steroid with Topical Nonsteroidal Anti-inflammatory Drug for Preventing Cystoid Macular Edema after Cataract Surgery in Patients with Epiretinal Membrane
Korean Journal of Ophthalmology ; : 394-401, 2017.
Article in English | WPRIM | ID: wpr-80658
ABSTRACT

PURPOSE:

To investigate the additive effect of oral steroid with topical nonsteroidal anti-inflammatory drug (NSAID) on cystoid macular edema (CME) in patients with epiretinal membrane (ERM) after cataract surgery.

METHODS:

Medical records of subjects who underwent uneventful cataract surgery (n = 1,349) were retrospectively reviewed; among these patients, those with pre-existing ERM (n = 81) were included. Patients were divided into two groups one group had postoperative administration of oral steroid for 1 week (n = 45) and the other group did not have oral steroid administration (n = 36). Changes in macular thickness and incidence of CME were compared in both groups. Topical NSAIDs were administered in both groups for 1 month postoperatively. Definite CME and probable CME were defined by changes in retinal contour with or without cystoid changes. Change in central macular thickness of more than three standard deviations (≥90.17 µm) was defined as possible CME. Macular thickness was measured at 1 month after the operation by optical coherence tomography.

RESULTS:

The incidence of definite, probable, and possible CME were 2.22%, 4.44%, and 8.89% with the use of steroid and 2.78%, 5.56%, and 8.33% without steroid, respectively (p = 0.694, p = 0.603, and p = 0.625), and regardless of treatment group, the incidences in these patients were higher compared to incidences in whole subjects (1.26%, 2.30%, and 4.32%; p = 0.048, p = 0.032, and p = 0.038, respectively). The differences in macular thickness were not statistically different between the two groups. Average changes of central foveal thickness in 3 mm and 6 mm zone were 29.29 µm, 35.93 µm, and 38.02 µm with the use of steroid and 32.25 µm, 44.08 µm, and 45.39 µm without steroid (p = 0.747, p = 0.148, and p = 0.077, respectively).

CONCLUSIONS:

This study suggests that administration of oral steroid may not have a synergistic effect in reduction of CME and retinal thickness in patients with pre-existing ERM after cataract surgery, when topical NSAIDs are applied.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Retinaldehyde / Cataract / Anti-Inflammatory Agents, Non-Steroidal / Macular Edema / Medical Records / Incidence / Retrospective Studies / Epiretinal Membrane / Tomography, Optical Coherence Type of study: Incidence study / Observational study / Prognostic study Limits: Humans Language: English Journal: Korean Journal of Ophthalmology Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Retinaldehyde / Cataract / Anti-Inflammatory Agents, Non-Steroidal / Macular Edema / Medical Records / Incidence / Retrospective Studies / Epiretinal Membrane / Tomography, Optical Coherence Type of study: Incidence study / Observational study / Prognostic study Limits: Humans Language: English Journal: Korean Journal of Ophthalmology Year: 2017 Type: Article