A Case of Removal Myoglobin by Plasmapheresis in Rhabdomyolysis / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 265-268, 2007.
Article
in Korean
| WPRIM
| ID: wpr-80662
ABSTRACT
Rhabdomyolysis is defined as necrosis of the skeletal muscle fibers with release of the intracellular muscle constituents, including myoglobins,into the blood and urine. Severe myoglobinemia causes obstruction and necrosis of the renal tubule, resulting in acute renal failure (ARF). In this case, a patient with rhabdomyolysis-induced ARF was in recovery phase after treatment with fluid replacement and continuous renal replacement therapy (CRRT). However, a sudden relapse of severe myoglobinemia occurred during CRRT. To remove myoglobinas rapidly as possible, we applied two sessions of plasmapheresis (total plasma exchange, TPE) in addition to CRRT for two days. The myoglobin level of the patient successfully decreased by 91%, and clinical symptoms and laboratory-measuredabnormalities subsequently improved. If severe myoglobinemia is persistent, or if relapse in spite of CRRT occurs, it would be reasonable to consider TPEas an additional therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma Exchange
/
Recurrence
/
Rhabdomyolysis
/
Plasmapheresis
/
Renal Replacement Therapy
/
Muscle Fibers, Skeletal
/
Acute Kidney Injury
/
Myoglobin
/
Necrosis
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
2007
Type:
Article
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