Effect of Mercury Chloride on Humoral and Cell-mediated Immune Responses in Mice / 예방의학회지
Korean Journal of Preventive Medicine
;
: 27-42, 1995.
Article
in Korean
| WPRIM
| ID: wpr-8069
ABSTRACT
The in vivo and in vitro humoral and cell-mediated immune responses of lymphocytes of BALB/c mouse exposed to mercury chloride(HgC12) were investigated. In vitro exposure of the splenocytes to mercury chloride produced overt cytotoxicity in 3 hours period. The IC50(the concentration required to inhibit a splenocyte viability by 50%) for mercury chloride was >0.1mM for cytotoxicity. In vivo mercury chloride exposed mice were significantly depressed delayed type hypersensitivity(DTH) response to sheep red blood cells(SRBC) in a dose-dependent manner compared with control group. Mercury chloride inhibited the proliferative responses of splenocytes to lipopolysaccharide. pokeweed mitogen, concanavalin A and phytohemagglutinin in a dose-dependent manner. Hemagglutinin response to SRBC in mercury chloride exposed mice was significantly depressed in a dose-dependent manner compared with control group. After 7 weeks of mercury chloride exposure in vivo. mercury chloride induced an increase of nonspecific serum IgG1 and IgE levels in BALB/c mice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin E
/
Immunoglobulin G
/
Sheep
/
Lymphocytes
/
Concanavalin A
/
Phytolacca americana
/
Hemagglutinins
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Preventive Medicine
Year:
1995
Type:
Article
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