Regulation of Wnt/β-catenin signaling in bone development and bone tumor / 中华外科杂志
Chinese Journal of Surgery
; (12): 797-800, 2018.
Article
in Zh
| WPRIM
| ID: wpr-807483
Responsible library:
WPRO
ABSTRACT
The Wnt/β-catenin signaling pathway is crucial in bone development and homeostasis.Normally, it has been suggested to play a significant role in regulation of osteogenic differentiation of bone marrow mesenchymal stem cells, osteoclastogenesis and?偅ibone mineral density. Dysregulated Wnt/β-catenin signaling pathway is responsible for bone tumor, metabolic bone disease, degenerative bone disease and it related to development and invasion of osteosarcoma and Ewing′s sarcoma.Studies of the molecular mechanisms of Wnt/β-catenin signaling pathway provide theoretical basis of a potential target for bone diseases.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Surgery
Year:
2018
Type:
Article