Clinical efficacy of dexamethasone combined with budesonide in the treatment of children with acute infectious laryngitis / 中国基层医药

ABSTRACT

Objective@#To investigate the clinical efficacy of dexamethasone combined with budesonide in the treatment of children with acute infectious laryngitis.@*Methods@#From May 2014 to May 2017, 85 children with acute infectious laryngitis in our hospital were randomly divided into observation group(43 cases) and control group(42 cases) according to the digital table.The control group was treated with dexamethasone, the observation group inhaled budesonide on the basis of the dexamethasone treatment.The clinical effect was compared between the two groups.@*Results@#The effective rate of the observation group was significantly higher than that of the control group(97.9% vs.85.7%), the difference was statistically significant(χ2=4.022, P<0.05). The symptoms disappeared time of laryngeal obstruction [(1.2±0.2)d vs.(1.8±0.4)d], hoarseness [(2.2±0.6)d vs.(2.7±0.9)d], dyspnea [(1.5±0.4)d vs.(2.2±0.6)d], fever [(2.3±0.7)d vs.(3.0±0.9)d]and cough [(5.1±1.2)d vs.(6.7±1.7)d], the hospitalization time [(6.7±1.3)d vs.(8.9±1.9)d]in the observation group were significantly shorter than those in the control group (t=8.778, 3.020, 6.343, 4.008, 5.023, 6.243, all P<0.05). There was no statisticallysignificant difference in the incidence rate of adverse reactions between the two groups(χ2=0.508, P>0.05).@*Conclusion@#The combination of dexamethasone and budesonide in the treatment of acute infectious laryngitis can significantly improve the therapeutic effect, shorten the time of improvement of clinical symptoms, and with high safety, so it is worthy of clinical application.