Efficacy, toxicity and prognosis analysis of three-dimensional conformal radiotherapy combined with concurrent chemotherapy for locally advanced cervical cancer / 中国基层医药

ABSTRACT

Objective@#To explore the efficacy, toxicity and prognosis of three-dimensional conformal radiotherapy combined with concurrent chemotherapy for locally advanced cervical cancer.@*Methods@#From January 2014 to January 2015, 96 patients with locally advanced cervical cancer in Yuncheng Central Hospital were selected and randomly divided into radiotherapy group and concurrent chemoradiotherapy group according to the digital table, with 48 cases in each group.The radiotherapy group received CT based three-dimensional conformal radiotherapy and three-dimensional 192Ir after loading irradiation technology, the concurrent chemotherapy group received docetaxel plus cisplatin chemotherapy synchronous three-dimensional conformal radiotherapy and three-dimensional 192Ir after loading irradiation technology.The clinical effect, 2-year survival rate, liver function injury, leukopenia and incidence of side effects, survival of patients and Karnofsky score before and after treatment were compared between the two groups.@*Results@#The effective rate of chemoradiotherapy of the concurrent chemoradiotherapy group was 75.00%, which was higher than 50.00% of the radiotherapy group (χ2=4.181, P<0.05). The 2-year survival rates of the two groups were 75.00%, 95.83%, respectively, which of the concurrent chemoradiotherapy group was higher than that of the radiotherapy group.In the radiotherapy group, 12 cases of liver function injury, white cells reduced in 10 cases, 36 cases of gastrointestinal reaction, 13 cases of nervous system reaction, 1 case of renal injury.In the concurrent chemoradiotherapy group, liver function injury in 11 cases, 14 cases with leukopenia, 30 cases of gastrointestinal reaction, 13 cases of nervous system reaction, 1 case of renal injury, and there were no statistically significant differences between the two groups(all P>0.05). Before treatment, the living conditions and Karnofsky score had no statistically significant differences between the two groups (all P>0.05). After treatment, the survival and Karnofsky score improved more significantly in the concurrent chemoradiotherapy group, the differences were statistically significant(all P<0.05).@*Conclusion@#The curative effect of three dimensional conformal radiotherapy combined with concurrent chemotherapy on locally advanced cervical cancer is definite, and it can improve the prognosis of patients with high safety.As to liver function damage, leukocyte depletion and other toxic side effects, there are no statistically significant differences between two groups, so it is worthy of popularizing.