Hereditary Colon Cancer: Lynch Syndrome
Gut and Liver
;
: 151-160, 2010.
Article
in English
| WPRIM
| ID: wpr-80812
ABSTRACT
Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR) genes. A comprehensive family history is one important way to identify at-risk individuals. The elucidation of the molecular genetics of this syndrome has made it possible to screen for the disorder with molecular tests. Microsatellite instability and/or immunohistochemistry followed by germline testing for mutations in MMR genes is now a standard approach for clinically suspected cases. Correctly recognizing Lynch syndrome is essential for the application of appropriate screening and surveillance measures. Close surveillance and risk-reducing operations can decrease cancer-related mortality. In addition, counseling is an important component of the management of any family with Lynch syndrome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunohistochemistry
/
Colorectal Neoplasms
/
Colorectal Neoplasms, Hereditary Nonpolyposis
/
Mass Screening
/
Colon
/
Colonic Neoplasms
/
Germ-Line Mutation
/
Counseling
/
Microsatellite Instability
/
DNA Mismatch Repair
Type of study:
Screening study
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2010
Type:
Article
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