A Case of Fatal DRESS Syndrome Caused by Dapsone in a Patient with Behcet's Syndrome / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 253-257, 2009.
Article
in Korean
| WPRIM
| ID: wpr-80920
ABSTRACT
Dapsone has been used for several dermatological conditions such as immunobullous disease and ulticarial vasculitis. Dapsone is very useful drug for treating the mucocutaneous manifestations of Behcet's disease. The widely recognized side effects of dapsone are headache, methemoglobinemia and hemolysis. The severer, but rarer side effect of dapsone is known as dapsone hypersensitivity syndrome, which consists of exfoliative dermatitis, hepatitis, lymphadenopathy and hemolytic anemia. When this is associated with eosinophilia, we can diagnose and treat this drug reaction with eosinophilia and systemic symptoms (DRESS). DRESS is a syndrome of fever, rash, and internal organ involvement that's secondary to administering the offending medication. We describe here a 47-year-old woman who was hospitalized with fever, skin rash, hemolytic anemia, lymphadenopathy, eosinophilia, pleural effusion and life threatening hepatitis, which could lead to hepatic failure, within three weeks of starting of dapsone therapy for controlling her oral and genital ulcers. We diagnosed the woman as suffering with DRESS syndrome and we started treatment with corticosteroid. Three weeks after starting therapy, her symptoms almost completely resolved and she was discharged.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pleural Effusion
/
Stress, Psychological
/
Ulcer
/
Vasculitis
/
Behcet Syndrome
/
Liver Failure
/
Dermatitis, Exfoliative
/
Dapsone
/
Eosinophilia
/
Exanthema
Limits:
Female
/
Humans
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
2009
Type:
Article
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