Factors Associated with HIV-1 Proviral DNA Loads in Patients with Undetectable Plasma RNA Load
Journal of Korean Medical Science
;
: 152-154, 2009.
Article
in English
| WPRIM
| ID: wpr-8097
ABSTRACT
To evaluate factors associated with human immunodeficiency virus type 1 (HIV-1) proviral DNA load, we conducted a cross-sectional study of 36 chronically HIV-1- infected individuals with undetectable plasma viral RNA. We used real-time polymerase chain reaction to determine the number of HIV-1 proviral DNA copies per 10(6) peripheral blood mononuclear cells. The mean level of plasma viral RNA when the CD4+ T cell count was above 500 cells/microliter without highly active antiretroviral therapy (HAART) was significantly associated with proviral DNA load at the time of undetectable plasma HIV RNA with HAART. Strategies to reduce the level of plasma viral RNA when patients' CD4+ T cell counts are above 500 cells/microliter without HAART could help reduce HIV-1 proviral DNA load.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA, Viral
/
RNA, Viral
/
CD4-Positive T-Lymphocytes
/
HIV Infections
/
Polymerase Chain Reaction
/
Cross-Sectional Studies
/
HIV-1
/
Proviruses
/
Anti-HIV Agents
/
Antiretroviral Therapy, Highly Active
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2009
Type:
Article
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