The protective effects of dulaglutide on AD-like neurodegenerative changes / 天津医药
Tianjin Medical Journal
;
(12): 673-677, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-809736
ABSTRACT
@# Objective To investigate the protective effects of dulaglutide on Alzheimer’s disease (AD)-like neurodegenerativechangesanditsmechanismthereof. Methods Dulaglutide,anewdrugfordiabetes,wasappliedto observeandexploreAD-likeneurodegenerativechangesinducedbyPI3KinhibitorwortmannininSH-SY5Ycells.MTT assaywasusedtoobservethecellvitalityinducedbydulaglutide,wortmanninandglucagon-likepeptide(GLP-1)1receptor antagonistex9-39.WesternblotassaywasusedtodetectthelevelsofphosphorylatedTau,neurofilaments(NFs)andthe proteinsofPI3K/GSK-3βsignalingpathway.Results Dulaglutideimprovedtheimpairedvitality,increasedthelevelsof phosphorylatedPI3KandGSK-3βanddecreasedphosphorylationlevelsoftauandNFsinducedbywortmannininSHSY5Ycells.Ex9-39antagonizedtheeffectsofDulaglutide. Conclusion DulaglutideprotectsSH-SY5YcellsfromADlikeneurodegenerativechangesthroughimprovingPI3K/GSK-3βinsulinsignalingpathway.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tianjin Medical Journal
Year:
2018
Type:
Article
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