Relationship between plasma lipoprotein associated phospholipase A2 and coronary in-stent restenosis after percutaneous coronary intervention / 天津医药

ABSTRACT

@# Objective ToinvestigatetherelationshipbetweenplasmalipoproteinassociatedphospholipaseA2(LpPLA2)levelandin-stentrestenosis(ISR)afterpercutaneouscoronaryintervention(PCI).Methods Atotalof208patients treatedwithPCIandexaminedwithafollow-upcoronaryangiograph(CAG)wereincludedinthisstudy.Thepatientswere dividedinto2groupsbasedontheresultsofISRconditionISRgroup(n=29)andNISRgroup(n=179).Theplasmalevelsof Lp-PLA2weredetectedbeforefirst-PCIoperationandfollow-upCAGintwogroups.Thegeneralclinicaldata,biochemical parameters,coronarycoronariography,interventionalfeaturesandplasmalevelsofLp-PLA2werecomparedbetweenthetwo groups.LogisticregressionanalysiswasusedtoanalyzetheindependentriskfactorforISR.Receiveroperatingcharacteristic curvewasusedtoevaluatethepredictiveabilityoftheplasmalevelofLp-PLA2totheoccurrenceofISR.Results (1)In ISRgroup,patientswiththehistoryoftype2diabetes,levelsoflowdensitylipoproteincholesterol(LDL-C)andlevelsof glycosylatedhemoglobin(HbA1c)weresignificantlyhigherthanthoseinNISRgroup,whileserumlevelsoftotalbilirubin(TBIL)decreased,thelengthofthestentwaslonger,andstentdiameterwassmaller(P＜0.05).(2)InISRgroup,theLp-PLA2 level and ΔLp-PLA2 level were higher before first-PCI operation than those in NISR group (P＜0.05). (3) Logistic regressionanalysisshowedthatT-BIL,stentdiameterandΔLp-PLA2weretheindependentriskfactorsforISR(P＜0.05). (4)Thereceiveroperatingcharacteristiccurve(ROC)areaofΔLp-PLA2forpredictingpost-PCIISRoccurrencewas0.862, theoptimalcutoffvalueofΔLp-PLA2was20.68μg/L,thesensitivitywas79%,andthespecificitywas83%.Conclusion TheincreasedlevelofLp-PLA2afterPCIiscorrelatedwithISR,andtheregularmonitoringthelevelofLp-PLA2hassome significanceinforecastingISR.