Action Duration of Atracurium in the Elderly Patients / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 1071-1076, 1997.
Article
in Korean
| WPRIM
| ID: wpr-81028
ABSTRACT
BACKGROUND:
The effects of a muscle relaxant may differ in elderly compared with young adult patients for a variety of the pharmacokinetic and pharmacodynamic reasons. Atracurium is eliminated by nonorgan dependent pathway, Hofmann elimination and ester hydrolysis. So there are some arguments for age-related differences. The purpose of this study was to compare the differences of the onset and duration of atracurium in young and elderly.METHODS:
Eighteen young adults (21-54 yr) and 18 elderly (>65 yr) patients anesthetized with nitrous oxide and enflurane. Atracurium (0.5 mg/kg) was given and then intubation was performed after T1 response was blocked more than 80%. Neuromuscular relaxation was measured by the first twitch of train-of-four (T1) response at the adductor pollicis after supramaximal stimulation of ulnar nerve at 2Hz every 12 sec. The onset (disappearance of T1) and duration of 5, 25, 50, 75% recovery time of T1 and recovery index (time for 25-75% recovery of T1) were recorded.RESULTS:
Onset of block was not significantly different between the young and elderly. Recovery time of 5, 25, 50, 75% and recovery index were not prolonged in elderly compared with young adults.CONCLUSIONS:
There were no significant differences between young and elderly adults in onest time, recovery time of 5, 25, 50, 75% and recovery index when atracurium is used in a single bolus dose. The results suggest that atracurium in elderly patients has similar onset and action duration compared with younger patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Relaxation
/
Ulnar Nerve
/
Atracurium
/
Enflurane
/
Hydrolysis
/
Intubation
/
Nitrous Oxide
Limits:
Adult
/
Aged
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1997
Type:
Article
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