Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy
Immune Network
;
: 4-2020.
Article
in English
| WPRIM
| ID: wpr-811178
ABSTRACT
Tregs have a role in immunological tolerance and immune homeostasis by suppressing immune reactions, and its therapeutic potential is critical in autoimmune diseases and cancers. There have been multiple studies conducted on Tregs because of their roles in immune suppression and therapeutic potential. In tumor immunity, Tregs can promote the development and progression of tumors by preventing effective anti-tumor immune responses in tumor-bearing hosts. High infiltration of Tregs into tumor tissue results in poor survival in various types of cancer patients. Identifying factors specifically expressed in Tregs that affect the maintenance of stability and function of Tregs is important for understanding cancer pathogenesis and identifying therapeutic targets. Thus, manipulation of Tregs is a promising anticancer strategy, but finding markers for Treg-specific depletion and controlling these cells require fine-tuning and further research. Here, we discuss the role of Tregs in cancer and the development of Treg-targeted therapies to promote cancer immunotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
T-Lymphocytes, Regulatory
/
Tumor Microenvironment
/
Homeostasis
/
Immunotherapy
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Immune Network
Year:
2020
Type:
Article
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