Chemical constituents from the leaves of Anisopus mannii and the melanogenesis inhibitory activities / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 676-681, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-811772
ABSTRACT
@#The phytochemical studies on the leaves of Anisopus mannii led to the isolation of seven compounds by silica gel, ODS, DIAION HP-20, Sephadex LH-20 colunmn chromatographer, their structures were elucidated on the basis of the spectroscopic analyses(NMR, HRMS)and the comparisons with the literatures as 3β-acetoxylup-20(29)-ene(1), 1-acetoxy-2-isopropyl-1-tridecene(2), rutin(3), 3, 6′-diferuloylsucrose(4), 3-O-β-D-glucopyranosyl-3-β-hydroxyolean-12-en-28-oic acid 28-O-[α-L-rhamnopyra- nosyl-(1→2)-β-D-glucopyranosyl] ester(5), conduritol A(6), hoyacarnoside I(7). Meanwhile, the isolated compounds were evaluated for their inhibitory activities against melanogensis in B16 melanoma cells, as the results, all compounds exhibited melanogenesis-inhibitory activity and compound 5 showed a strongest activity(Melanin content (27. 4±3. 5)%, Cell Viability (54. 9±5. 6)% with a concentration of 30 μmol/L)which could be further developed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2018
Type:
Article
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