Determination of the related substances of tenofovir by RP-HPLC / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 78-80, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-811914
ABSTRACT
@#To investigate the related substances of tenofovir, 3 related substances were synthesized. RP-HPLC analytical method was developed using Agilent ZORBAX SB-C18 column. The mobile phase composed of methanol and 0. 02 mol/L potassium dihydrogen phosphate. Linear gradient elution was used and the detection wavelength was 260 nm. 3 impurities were found in tenofovir. The established method was accurate and reproducible, and it can be applied for the related substances test in tenofovir.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2015
Type:
Article
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