Advances in BET bromodomain protein inhibitors / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 264-271, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-811944
ABSTRACT
@#Recognizing acetyl-lysine of histone is a key process of epigenetic regulation that is mediated by a protein module called bromodomain(BRD). The bromodomain inhibitors of the bromodomains and extra-terminal(BET)family have shown great potential in anti-inflammatory and antiproliferative effects. Through a review of diseases and structures about BET bromodomain, different kinds of inhibitors were analyzed and their structure-activity relationships were summarized. Herenin, the recent advances reported are reviewed for discovering more excellent small molecule inhibitors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS