Expression of p75 neurotrophin receptor and its role in drug development / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 751-756, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-812003
ABSTRACT
@#p75 neurotrophin receptor(p75NTR)is a low-affinity nerve growth factor receptor. It can interact with a variety of ligands and intracellular factors to play the prosurvival or proapoptoticrole in the nervous system. Besides, it plays an important role in apoptosis and nerve regeneration as a member of tumor necrosis factor receptor(TNFR)superfamily. More recently, a close relationship between p75NTR expression and pluripotency has been described. Thus, understanding the function of p75NTR has been challenging because it mediates many different cellular activities depending on the specific cell type and itsphysiological state. This review focuses on the expression of p75NTR and potential drug development targeting p75NTR.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2015
Type:
Article
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