Three new anthraquinone derivatives isolated from Symplocos racemosa and their antibiofilm activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 944-949, 2017.
Article
in En
| WPRIM
| ID: wpr-812037
Responsible library:
WPRO
ABSTRACT
Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, H- and C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
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Physiology
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Proteus mirabilis
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Spectrophotometry, Infrared
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Mass Spectrometry
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Streptococcus mutans
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Chemistry
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Anthraquinones
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2017
Type:
Article