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Three new anthraquinone derivatives isolated from Symplocos racemosa and their antibiofilm activity / 中国天然药物
Article in En | WPRIM | ID: wpr-812037
Responsible library: WPRO
ABSTRACT
Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, H- and C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.
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Full text: 1 Index: WPRIM Main subject: Pharmacology / Physiology / Proteus mirabilis / Spectrophotometry, Infrared / Mass Spectrometry / Streptococcus mutans / Magnetic Resonance Spectroscopy / Microbial Sensitivity Tests / Chemistry / Anthraquinones Language: En Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2017 Type: Article
Full text: 1 Index: WPRIM Main subject: Pharmacology / Physiology / Proteus mirabilis / Spectrophotometry, Infrared / Mass Spectrometry / Streptococcus mutans / Magnetic Resonance Spectroscopy / Microbial Sensitivity Tests / Chemistry / Anthraquinones Language: En Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2017 Type: Article