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Neuroprotective effects of Yiqihuoxue calm wind capsule on ischemic stroke in rats / 中国天然药物
Article in English | WPRIM | ID: wpr-812059
Responsible library: WPRO
ABSTRACT
Stroke remains the third leading cause of death and of adult disability worldwide. Vascular occlusion, followed by ischemic cascade, leads to irreversible tissue injury. Recombinant tissue plasminogen activator is the only FDA approved drug for the current treatment of acute ischemic stroke. However, traditional Chinese medicine has a long history and rich clinical experience in the treatment and rehabilitation of ischemic stroke. Using a classical middle cerebral artery occlusion (MCAO) stroke model, we tested the effectiveness of Yiqihuoxue calm wind (YCW) capsule on neurological function, gross pathology and oxidative stress status in MCAO rats. YCW capsule (3.36 and 6.72 g·kg of crude drug) could significantly lower Longa's score and superoxide dismutase (SOD) level, together with less necrotic cells and infarcted area. In addition to elevated MDA and downregulated iNOS expression, YCW capsule exhibited its neuroprotective effects via free radical scavenging and NO inhibition.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rats / Superoxide Dismutase / Humans / Male / Brain Ischemia / Rats, Sprague-Dawley / Oxidative Stress / Neuroprotective Agents / Stroke / Drug Therapy Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rats / Superoxide Dismutase / Humans / Male / Brain Ischemia / Rats, Sprague-Dawley / Oxidative Stress / Neuroprotective Agents / Stroke / Drug Therapy Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2017 Type: Article