Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 674-679, 2017.
Article
in English
| WPRIM
| ID: wpr-812069
ABSTRACT
Microglial activation and resultant neuroinflammatory response are implicated in various brain diseases including Alzheimer's disease and Parkinson's disease. Treatment with anti-neuroinflammatory agents could provide therapeutic benefits for such disorders. Protosappanin A (PTA) is a major bioactive ingredient isolated from Caesalpinia sappan L.. In this work, the anti-neuroinflammatory effects of PTA on LPS-stimulated BV2 cells were investigated and the underlying mechanisms were explored. Results showed that PTA significantly inhibited the production of TNF-α and IL-1β in LPS-activated BV2 microglia. Moreover, the mRNA expressions of IL-6, IL-1β, and MCP-1 were reduced by PTA in a dose-dependent manner. Furthermore, PTA suppressed JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3, as well as STAT3 nuclear translocation against LPS treatment. These observations suggested a novel role for PTA in regulating LPS-induced neuroinflammatory injuries.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phenols
/
Signal Transduction
/
Lipopolysaccharides
/
Tumor Necrosis Factor-alpha
/
Microglia
/
Drug Therapy
/
Allergy and Immunology
/
STAT3 Transcription Factor
/
Interleukin-1beta
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2017
Type:
Article
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