Tagetones A and B, new cytotoxic monocyclic diterpenoids from flowers of Tagetes minuta / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 546-549, 2017.
Article
in English
| WPRIM
| ID: wpr-812082
ABSTRACT
Tagetones A (1) and B (2), two new monocyclic diterpenoids were isolated from the n-hexane fraction of fresh flowers of Tagetes minuta L. (Asteraceae). Their structures were established by multiple spectroscopic methods (IR, HR-ESI-MS, and 1D-, and 2D-NMR), in addition to comparison with literature data. Compound 1 showed cytotoxic activity towards MCF7 and A549 cancer cells with IC values being 4.68 and 4.24 µmol·L, respectively, compared to doxorubicin (IC 0.13 and 1.12 µmol·L, respectively). Compound 2 also exhibited significant activity against HCT116 cancer cells (IC, 6.30 µmol·L).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plant Extracts
/
Cell Survival
/
Chemistry
/
Tagetes
/
Flowers
/
Cell Line, Tumor
/
Diterpenes
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2017
Type:
Article
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