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Flavonoids isolated from Sinopodophylli Fructus and their bioactivities against human breast cancer cells / 中国天然药物
Article in En | WPRIM | ID: wpr-812120
Responsible library: WPRO
ABSTRACT
Four prenylated flavonoids compounds 1-4, named sinopodophyllines A-D, and a flavonoid glycoside (compound 13), sinopodophylliside A, together with 19 known compounds (compounds 5-12 and 14-24) were isolated from the fruits of Sinopodophyllum hexandrum. The structures of new compounds were elucidated by extensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compounds 1-6, 9-11, and 14-17 were tested for their cytotoxicity against human breast-cancer T47D, MCF-7 and MDA-MB-231 cells in vitro, and compounds 2, 5, 6, 10 and 11 showed significant cytotoxicity (IC values < 10 μmol·L) against T47D cells.
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Full text: 1 Index: WPRIM Main subject: Pharmacology / Flavonoids / Breast Neoplasms / Molecular Structure / Chemistry / Berberidaceae / Cell Line, Tumor / Cell Proliferation / Drug Therapy / Fruit Limits: Humans Language: En Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2017 Type: Article
Full text: 1 Index: WPRIM Main subject: Pharmacology / Flavonoids / Breast Neoplasms / Molecular Structure / Chemistry / Berberidaceae / Cell Line, Tumor / Cell Proliferation / Drug Therapy / Fruit Limits: Humans Language: En Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2017 Type: Article